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Two dysfunctional couples rent a modern luxury desert home for the weekend hoping to sort out their messed-up lives. Just as they are about to settle in for a fun night, a neighbour turns up at their front door saying she has car trouble. And that's when the murderous trouble really starts. Because without knowing it, the four friends have landed slap-bang in the wrong violent ...。周振华（罗嘉良 饰）是一名肿瘤内科主治医师，和妻子陶琳（苏岩 饰）结婚多年，彼此之间感情依然十分亲密。然而这幸福的一切在周振华三十六岁生日之后发生了翻天覆地的改变，丈夫的突然冷漠让陶琳百思不得其解。而周振华的初恋情人李京的出现亦让陶琳开始怀疑，丈夫是否变了心。 让陶琳没有想到的是，旧情人张斌（房斌 饰）亦出现在了自己的身边，面对残酷的现实和温情的往昔，陶琳的内心里产生了强烈的动摇。电视台记者楚虹（白冰 饰）是张斌的女友，男友近日里反常的举动让她开始调查陶琳的身世和过去。随着调查的深入，周振华和陶琳的秘密渐渐浮出了水面。。《德云社德云五队小园子三里屯剧场站》由五队队长烧饼带领德云社五队为观众带来精彩的相声演出。。